The objective of the symposium is to discuss state-of-the-art multidisciplinary issues bridging the humanities and the applied sciences related to 3D modeling, visualization, and analysis—including engineering evaluations—of complex archaeological structures and data. The one-day symposium consists of presentations followed by a roundtable. Leading researchers will outline current work and cutting-edge applications in virtual archaeology and digital humanities as well as in image processing, dynamic monitoring and structural analysis of monuments. In the following roundtable, invited participants will discuss how they use or envision use of 3D digital modeling in their present or future research or in the field of material cultural heritage broadly conceived.